Ln Bio-Inorganic Chemistry | Molecular Magnetism | Intermediate Valency
Ln/An Synthesis | Rare Earth Separations

The recent discovery and crystallization of a rare earth element-dependent methanol dehydrogenase enzyme has inspired our group to investigate the active site, which is composed of a lanthanide cation and a pyrroloquinoline quinone cofactor.1,2 We are characterizing the active site using DFT methods together with the synthesis model complexes and reactivity studies. We expect that understanding of the unique electronics of the active site will allow us to prepare new lanthanide-based methanol dehydrogenation catalysts.

1   Pol, A.; Barends, T. R. M.; Dietl, A.; Khadem, A. F.; Eygensteyn, J.; Jetten, M. S. M.; Op den Camp, H. J. M.;
      Environ. Microbiol. 2014, 16, 255.
2    Bogart, J. A.; Lewis, A. J.; Schelter, E. J., Chem. Eur. J. 2014, accepted.